Aurell, Erik and Brown, Stanley and Johansson, Johan (2002) Stability puzzles in phage lambda. Physical Review E, 65 (5).
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Official URL: http://prola.aps.org/abstract/PRE/v65/i5/e051914
In the absence of RecA-mediated cleavage of the repressor, the [lambda] prophage is exceptionally stable. We develop a stochastic model that predicts the stability of such epigenetic states from affinities of the molecular components. We find that the stability, in particular, depends on the maximum possible cI protein production, and on the number of cro proteins per transcribed mRNA. We apply the model to the behavior of recently published mutants of OR and find, in particular, that a mutant that overexpress cro behaves in a different way than what was predicted, thus suggesting that the current view of the OR switch is incomplete. The approach described here should be generally applicable to the stability of expressed states.
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|Deposited On:||08 Sep 2009|
|Last Modified:||12 Dec 2014 13:31|
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